Meyer Shank Racing was formed in 1989 when Mike Shank first began racing cars professionally. Shank retired from the cockpit in 1997 to focus his efforts on running the team, which quickly found success in Champ Car's Toyota Atlantic Championship.
With several race wins under his belt, Shank was named as Team Owner of the Year twice in four years. Michael Shank Racing then joined the GRAND-AM Rolex Sports Car Series in 2004 in the Daytona Prototype ranks. The race-winning team scored a dramatic victory in the 50th Anniversary Rolex 24 At Daytona in 2012 and was invited to race in the 2016 24 Hours of Le Mans.
In 2017, MSR was selected to run Acura Motorsports' factory GTD effort in IMSA WeatherTech competition, helping the Acura NSX achieve two wins and two podiums and made its debut entry in the Indianapolis 500 with Jack Harvey. The newly renamed Meyer Shank Racing's crew chief Adam Rovazzini earned the prestigious Clint Brawner Award for the group's effort at the 500.
In 2018, the team contested six NTT INDYCAR SERIES races with Harvey in a technical partnership with Arrow Schmidt Peterson Motorsports and will continue the alliance in 2019 with Harvey competing in 10 races.
In late 2019, it was announced that Meyer Shank Racing would be competing full time in the NTT INDYCAR SERIES for both 2020 and 2021, in a technical alliance with Andretti Autosport, with Jack Harvey continuing as the driver of the No. 60 AutoNation SiriusXM Honda.